Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 590, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119946
Keywords
Hydroxyapatite; MWCNT; Spray Pyrolysis; Implant; Osteoblast
Categories
Funding
- Ministry of Human Resource Development (MHRD)
- Ministry of Electronics and Information Technology (MeitY)
- Nanomission, Department of Science and Technology (DST), Govt. of India
Ask authors/readers for more resources
The aim of the present work is to study the potential change in the antibacterial properties of Cu-hydroxyapatite/functionalized multiwall carbon nanotube (HA/f-MWCNT) composite coated heterogeneous implant surfaces against Gram positive and Gram-negative microorganism and to reveal the possible contribution of surface corrosion effects arising in stimulated body fluid. Novel spray pyrolysis instrument designed with double nozzle was used for the fabrication of Cu-hydroxyapatite/f-MWCNT film on 316L stainless steel (SS). The Cu-hydroxyapatite/MWCNT coated bioimplant was characterized by a series of techniques to identify the crystallinity, chemical bonds, surface morphology and elemental composition. The results disclose that the coated implants exhibit highly crystalline nature with the space group of P6(3mc) and spherical shaped morphology. The corrosion current density revealed a remarkable decrease from 6.8 to 3.8 mu A suggesting that the Cu substituted hydroxyapatite/f-MWCNT composite coating provided higher barrier properties which is beneficial to achieve higher corrosion protection of 316L SS implant. The hybrid Cu-hydroxyapatite-MWCNT composite revealed better antibacterial ability than HA/MWCNT for both gram positive and gram-negative bacteria with a maximum inhibition zone of 13-17 mm, compared with hydroxyapatite/f-MWCNT. The antibacterial ability of the Cu-hydroxyapatite/f-MWCNT nanocomposites was effective against Escherichia coli compared with other microorganisms. The Cu-hydroxyapatite/f-MWCNT nanocomposite exhibited that the coated material is nontoxic, biocompatible and suitable for biomedical application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available