Ni-Catalyzed stereoselective difunctionalization of alkynes

Tri- and tetrasubstituted olefins are widely present in biologically active molecules and functional materials. However, the methods for the stereoselective construction of such moieties are still very limited and extremely challenging. The transition-metal-catalyzed difunctionalization of alkynes is one of the most straightforward and effective choices. In this review, we summarize the progress of the nickel-catalyzed alkyne difunctionalization reaction, with an emphasis on the strategy and control of stereochemistry.