Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 87, Pages 13445-13448Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06034h
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Funding
- National Natural Science Foundation of China [22074088, 21622507]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT 15_R43]
- Fundamental Research Funds for the Central Universities [GK201803026, GK201802016, GK201901003]
- Natural Science Foundation of Shaanxi Province [2020JQ-407]
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A CRISPR-Cas12a-based strategy is developed for sensitive microRNA sensing, in which hyperbranched rolling circle amplification and transcription are integrated for the activation of the trans-cleavage ability of Cas12a. The integrated triplex signal amplification endows the strategy with a low background and high sensitivity. This design expands the scope of the CRISPR-Cas-based sensing toolbox and shows great potential in biological and biomedical studies.
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