Journal
COMMUNICATIONS CHEMISTRY
Volume 3, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s42004-020-00409-7
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Funding
- ACT-X (Japan Science and Technology Agency) [JPMJAX1915]
- KAKENHI (Japan Society for the Promotion of Science) [18K14281, 17K07181]
- Leading Initiative for Excellent Young Researchers (Ministry of Education, Culture, Sports, Science and Technology-Japan)
- Grants-in-Aid for Scientific Research [17K07181] Funding Source: KAKEN
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Dimethyl sulfoxide (DMSO) is widely used as a solvent in the life sciences, however, it is somewhat toxic and affects cell behaviours in a range of ways. Here, we propose a zwitterionic liquid (ZIL), a zwitterion-type ionic liquid containing histidine-like module, as a new alternative to DMSO. ZIL is not cell permeable, less toxic to cells and tissues, and has great potential as a vehicle for various hydrophobic drugs. Notably, ZIL can serve as a solvent for stock solutions of platinating agents, whose anticancer effects are completely abolished by dissolution in DMSO. Furthermore, ZIL possesses suitable affinity to the plasma membrane and acts as a cryoprotectant. Our results suggest that ZIL is a potent, multifunctional and biocompatible solvent that compensates for many shortcomings of DMSO. Dimethyl sulfoxide is a commonly used solvent, but its permeability and effect on cells is problematic. Here, an alternative solvent, a zwitterion-type ionic liquid, and its plasma membrane affinity as well as cryo-protecting property and drug-dissolution ability are reported.
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