Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 94, Pages 14825-14828Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06777f
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A cinchona alkaloid squaramide promoted enantioselective [4+2] cyclization between hydroxymaleimides and ortho-hydroxyphenyl p-QMs has been disclosed, and a wide range of chiral hemiketals containing chromane and succinimide frameworks with two adjacent quaternary stereogenic centers have been prepared for the first time with excellent results (up to 99% yield, up to 99 : 1 dr, up to >99% ee) under mild conditions.
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