Journal
VIRUSES-BASEL
Volume 12, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/v12111233
Keywords
yellow fever; epidemic; epidemiology; ecology; public health; Brazil
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq/MCTI) [440593/2016-6]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) Yellow Fever grant 2018
- National Institutes of Health (NIH) [NIHR01AI149614]
- US BRAZIL COLLABORATIVE BIOMEDICAL RESEARCH PROGRAM-CNPq/MS/NIH [404192/2019-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES/MEC)
- Departamento de Ciencia e Tecnologia (DECIT)
- Secretaria de Ciencia, Tecnologia, Inovacao e Insumos Estrategicos em Saude (SCTIE)
- Ministerio da Saude and Pro-Reitoria de Pesquisa/UFMG (PRPq-UFMG)
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Yellow fever (YF) is a re-emerging viral zoonosis caused by the Yellow Fever virus (YFV), affecting humans and non-human primates (NHP). YF is endemic in South America and Africa, being considered a burden for public health worldwide despite the availability of an effective vaccine. Acute infectious disease can progress to severe hemorrhagic conditions and has high rates of morbidity and mortality in endemic countries. In 2016, Brazil started experiencing one of the most significant YF epidemics in its history, with lots of deaths being reported in regions that were previously considered free of the disease. Here, we reviewed the historical aspects of YF in Brazil, the epidemiology of the disease, the challenges that remain in Brazil's public health context, the main lessons learned from the recent outbreaks, and our perspective for facing future YF epidemics.
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