Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 163, Issue -, Pages 1677-1686Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.09.117
Keywords
Polysaccharides; Structure characterization; Anti-inflammatory
Funding
- National Natural Science Foundation of China [31900919]
Ask authors/readers for more resources
A homogenous polysaccharide from Codonopsis pilosula (CPP) was isolated and identified to be an inulin-type fructan, coded as CPP1-2-1. The polysaccharide exhibited anti-inflammatory effect against lipopolysaccharide (LPS) induced RAW264.7 cells in vitro and dextran sodium sulfate (DSS)-induced colitis mice in vivo. Moreover, the expression of cytokines was further detected by qPCR, and the results showed that the polysaccharides can reduce the expression of inflammatory factors such as TLR4, NF-kappa B, TNF-alpha and IL-6 in the cells, indicating the anti-inflammatory activities may be achieved by inhibiting the activation of TLR4/NF-kappa B pathway. (C) 2020 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available