Journal
REGENERATIVE MEDICINE
Volume 15, Issue 10, Pages 2181-2192Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2020-0082
Keywords
alveolar bone cells; anticoagulant; autologous growth factors; citrate; plasma rich in growth factors; regenerative therapies; release kinetic
Categories
Ask authors/readers for more resources
Aim: This study investigated the effect of sodium citrate on the properties and biological activity of plasma rich in growth factors (PRGF). Methods: PRGF was obtained from trisodium citrate and plain extraction tubes. Hematological parameters, growth factors' release kinetics from both PRGF clots and their releasates' biological effect on human bone cells were evaluated. Results: The platelet enrichment factor, the growth factors' content and the release kinetic of PRGF were similar for both groups. The proliferation, collagen type I synthesis and tissue-nonspecific alkaline phosphatase activity of human osteoblasts showed no statistically significant differences. Conclusion: The use of sodium citrate does not influence the composition, the growth factors' release kinetics or the biological effect of PRGF, but it increases its clinical versatility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available