4.7 Article

Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 89, Pages 13756-13759

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04491a

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan [JP20K20440]
  2. Government of Japan

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We report a new series of lipid-based biocompatible ionic liquids (LBILs) consisting of the long-chain phosphonium compound 1,2-dimyristoyl-sn-glycero-3-ethyl-phosphatidylcholine as the cation and the long-chain fatty acids stearic acid, oleic acid, or linoleic acid as anions. Thesematerials were found to be completely miscible with many polar and nonpolar organic solvents as well as dispersible in water. These LBILs also exhibited excellent biocompatibility with an artificial three-dimensional human epidermis model.

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