Journal
GUT MICROBES
Volume 12, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2020.1851986
Keywords
Gut vascular barrier; alcoholic liver disease; Akkermansia muciniphila
Categories
Funding
- excellence initiative VASCage (Centre for Promoting Vascular Health in the Ageing Community)
- R&D K-Centre (COMET program - Competence Centers for Excellent Technologies) - Austrian Ministry for Digital and Economic Affairs
- ERC [615735]
- AIRC [IG 22026 2018]
- AIRC 5 x 1000 [UniCanVax 22757]
- federal state Tyrol
- federal state Salzburg
- federal state Vienna
- European Research Council (ERC) [615735] Funding Source: European Research Council (ERC)
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The translocation of bacterial components from the intestinal lumen into the portal circulation is crucial in the pathogenesis of alcoholic liver disease (ALD). Recently the important role of the gut vascular barrier (GVB) was elucidated in alcoholic liver disease. Here we report about the influence of A. muciniphila supplementation in experimental ALD on the GVB. Ethanol feeding was associated with increased Pv-1, indicating altered endothelial barrier function, whereas A. muciniphila administration tended to restore GVB. To further investigate GVB in experimental ALD, beta-catenin gain-of-function mice, which display an enhanced GVB, were ethanol-fed. beta-catenin gain-of-function mice were not protected from ethanol-induced liver injury, suggest an alternative mechanism of ethanol-induced GVB disruption. The description of the GVB in ALD could pave the way for new therapeutic options in the future.
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