Journal
AGING AND DISEASE
Volume 11, Issue 6, Pages 1537-1566Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2020.0225
Keywords
oxidative stress; stroke; subarachnoid hemorrhage; intracerebral hemorrhage; depression; mitochondrial dysfunction; antioxidant; aging
Categories
Funding
- China Postdoctoral Science Foundation [2017M612010]
- National Natural Science Foundation of China [81701144, 81371433, 8187 0916]
- Major Science and Technology project in medical and health of Zhejiang Province [WKJ-ZJ1615:2016149634]
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Epidemiologic studies have shown that in the aging society, a person dies from stroke every 3 minutes and 42 seconds, and vast numbers of people experience depression around the globe. The high prevalence and disability rates of stroke and depression introduce enormous challenges to public health. Accumulating evidence reveals that stroke is tightly associated with depression, and both diseases are linked to oxidative stress (OS). This review summarizes the mechanisms of OS and OS-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. Pathological changes can lead to neuronal cell death, neurological deficits, and brain injury through DNA damage and the oxidation of lipids and proteins, which exacerbate the development of these two disorders. Additionally, aging accelerates the progression of stroke and depression by overactive OS and reduced antioxidant defenses. This review also discusses the efficacy and safety of several antioxidants and antidepressants in stroke and depression. Herein, we propose a crosstalk between OS, aging, stroke, and depression, and provide potential therapeutic strategies for the treatment of stroke and depression.
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