Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 90, Pages 13999-14002Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06147f
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Funding
- National Key R&D Program of China [2018YFA0507501]
- National Natural Science Foundation of China [22074019, 22004017, 21425518]
- Shanghai Sailing Program [20YF1405300]
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Hydrophilic Fe3O4@PDA@UIO-66-NH2 is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins via LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.
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