4.7 Article

Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 90, Pages 13959-13962

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc05263a

Keywords

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Funding

  1. National Natural Science Foundation of China [21472070, 21602084]
  2. Social Development Key Project of Jiangsu Province [BE2019632]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions
  4. 111 Project [111-2-06]
  5. China Postdoctoral Science Foundation [BX20200153, 2018M632227]
  6. Open Foundation of Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of Education [KLCCB-KF202006]
  7. National First-class Discipline Program of Food Science and Technology [JUFSTR20180101]

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Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA), a weakly immunogenic carrier protein, for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.

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