4.7 Review

Nanoenzymes in disease diagnosis and therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 99, Pages 15513-15524

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc05427e

Keywords

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Funding

  1. Key Research and Development Program of Shandong Province [2018YFJH0502]
  2. National Natural Science Foundation of China [21535004, 91753111, 21927881, 21874086, 21775094, 21904075]
  3. National Key R&D Program of China [2019YFA0210100]
  4. Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province [2019KJC022]
  5. Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals [2019FCCEKL01]
  6. Open Foundation of Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University [2018KLMNP04]

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Nanoenzymes, as a new generation of artificial enzymes with highly effective enzyme-like properties, have come into focus and have achieved great progress. Considering the enormous potential of nanoenzymes in the field of disease diagnosis and treatment, such as biological detection, anti-inflammatory, anti-oxidative damage and cancer treatments, etc., we firstly summarize the wide range of bio-applications of different nanoenzymes in these fields. In this review, we discuss the factors influencing the properties of nanoenzymes such as pH and temperature, surface modification and doping of other elements. In addition, we introduce five kinds of nanoenzymes and their bio-applications in various diseases. The current review will make researchers better understand the current state of the development of nanoenzymes and may be beneficial for new breakthroughs.

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