Journal
CHEMICAL SOCIETY REVIEWS
Volume 49, Issue 24, Pages 8897-8909Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cs00474j
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Funding
- National Natural Science Foundation of China [21772161, 21622204]
- Natural Science Foundation of Fujian Province of China [2019J02001]
- President Research Funds from Xiamen University [20720180036]
- PCSIRT
- Science & Technology Cooperation Program of Xiamen [3502Z20183015]
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Over the past two decades, the development and application of ynamide chemistry have received more and more attention. Ynamides have proven to be versatile reagents for organic synthesis, and have been widely applied to the rapid assembly of a diverse range of structurally complex N-containing molecules, especially the valuable N-heterocycles. In comparison with the well-established transition metal-catalyzed reactions of ynamides, metal-free ynamide transformations have relatively seldom been exploited. Recently, Bronsted acid-mediated reactions of ynamides represent significant advances in ynamide chemistry. This review summarizes the latest trends and developments of Bronsted acid-mediated reactions of ynamides, including cycloaddition, cyclization, intramolecular alkoxylation-initiated rearrangement, oxygen atom transfer reactions and hydro-heteroatom addition reactions.
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