Journal
NEW JOURNAL OF CHEMISTRY
Volume 44, Issue 47, Pages 20776-20784Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj04016a
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Funding
- Natural Science Foundation of China [81571829]
- Open Project of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences [LSL-1907]
- Fundamental Research Funds for the Central Universities [lzujbky-2020-it29]
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Delayed wound healing caused by a lack of antibacterial properties and bioactivity limits the application of PVA hydrogel as a wound dressing. To break through these barriers, we developed a novel ternary hydrogel system composed of PVA, chitosan (Cs), and collagen (Col) through a facile physical cross-linking method. Based on the reasonable design and experimental verification, the synthesized PVA/Cs/Col hydrogel showed high mechanical strength, excellent antibacterial properties, and good biocompatibility. More importantly, it could effectively repair wound defects in a rat wound defect model 14 days after the operation, and the wound healing rate could reach 98.8%, which was far higher than those of other groups. Meanwhile, the healing wound tissue presented a continuous and thickened epidermis and more hair follicle structures appeared as confirmed by histological staining, further verifying its excellent repair effects on wound defects. Therefore, the facile and large-scale synthesis, low cost, and excellent repairability of the hydrogel imply its application potential in wound repair.
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