Journal
TRENDS IN CANCER
Volume 6, Issue 4, Pages 267-271Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2020.01.010
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Funding
- NATIONAL CANCER INSTITUTE [ZIABC010313] Funding Source: NIH RePORTER
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Tumor heterogeneity is a large conundrum in cancer medicine, making most therapeutic interventions palliative rather than curative. Here we discuss the implications of how molecularly targeted therapies in solid malignancies that promote limited cancer cell death may in fact make tumors more heterogeneous, increase aggressive phenotypes, and thus worsen patient outcomes.
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