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High-throughput analysis of DNA repair in microplates towards identification of inhibitors

Journal

GENES AND ENVIRONMENT
Volume 42, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s41021-020-00153-3

Keywords

DNA repair; Base excision repair; High-throughput analysis

Funding

  1. Japan Society for the Promotion of Science (JSPS) KAKENHI grant [JP 19H04278]

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Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will facilitate the identification of compounds that suppressively affect DNA repair.

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