Journal
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
Volume 37, Issue 8, Pages 1588-1601Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TCAD.2017.2760628
Keywords
Continuous-flow; microfluidic large-scale integration (mLSI); microfluidics; mixed integer linear programming; physical design
Categories
Funding
- Ministry of Science and Technology of Taiwan [MOST 105-2221-E-007-118-MY3, 104-2220-E-007-021]
- Technical University of Munich-Institute for Advanced Study, through the German Excellence Initiative
- European Union Seventh Framework Programme [291763]
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Continuous-flow microfluidic large-scale integration (mLSI) shows increasing importance in biological/chemical fields, thanks to its advantages in miniaturization and high throughput. Current mLSI is designed manually, which is time-consuming and error-prone. In recent years, design automation research for mLSI has evolved rapidly, aiming to replace manual labor by computers. However, previous design automation approaches used to design each microfluidic layer separately and oversimplify the layer interactions to various degrees, which resulted in a gap between realistic requirements and automatically generated designs. In this paper, we propose a module model library to accurately model microfluidic components involving layer interactions; and we propose a co-layout synthesis tool, Columba, which generates AutoCAD-compatible designs that fulfill all designs rules and can be directly used for mask fabrication. Columba takes plain-text netlist descriptions as inputs, and performs simultaneous placement and routing for multiple layers while ensuring the planarity of each layer. We validate Columba by fabricating two of its output designs. Columba is the first design automation tool that can seamlessly synchronize with the manufacturing flow.
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