Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 64, Issue 1, Pages 16-27Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2016.2535311
Keywords
Blood vessel segmentation; conditional random fields (CRFs); fundus imaging; structured output support vector machine (SOSVM)
Categories
Funding
- Internal Funds KU Leuven
- ERC [259112, FP7-MC-CIG 334380]
- ANPCyT [PICT 2010-1287, PICT 2014-1730]
- CONICET
- European Research Council (ERC) [259112] Funding Source: European Research Council (ERC)
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Goal: In this work, we present an extensive description and evaluation of our method for blood vessel segmentation in fundus images based on a discriminatively trained fully connected conditional random field model. Methods: Standard segmentation priors such as a Potts model or total variation usually fail when dealing with thin and elongated structures. We overcome this difficulty by using a conditional random field model with more expressive potentials, taking advantage of recent results enabling inference of fully connected models almost in real time. Parameters of the method are learned automatically using a structured output support vector machine, a supervised technique widely used for structured prediction in a number of machine learning applications. Results: Our method, trained with state of the art features, is evaluated both quantitatively and qualitatively on four publicly available datasets: DRIVE, STARE, CHASEDB1, and HRF. Additionally, a quantitative comparison with respect to other strategies is included. Conclusion: The experimental results show that this approach outperforms other techniques when evaluated in terms of sensitivity, F1-score, G-mean, and Matthews correlation coefficient. Additionally, it was observed that the fully connected model is able to better distinguish the desired structures than the local neighborhood-based approach. Significance: Results suggest that this method is suitable for the task of segmenting elongated structures, a feature that can be exploited to contribute with other medical and biological applications.
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