Journal
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
Volume 11, Issue 3, Pages 510-522Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2016.2646901
Keywords
Active electrode; active probe; biopotential; implantable device; low-noise amplifier; multi-electrode array; neural amplifier; neural probe; neural recording
Funding
- Howard Hughes Medical Institute
- Allen Institute of Brain Science
- University College London
- Gatsby Charitable Foundation
- Wellcome Trust
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In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13-mu m SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 mu m wide, 10 mm long, 20 mu m thick), achieving a crosstalk of -64.4 dB. The probe base (5 x 9 mm(2)) implements dual-band recording and a 171.6 Mbps digital interface. Measurement results show a total input-referred noise of 6.4 mu V-rms and a total power consumption of 49.1 mu W/channel.
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