Journal
JOURNAL OF CELL SCIENCE
Volume 133, Issue 21, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.250449
Keywords
FGF2; Fibroblast growth factor 2; IL-1 beta; Interleukin 1 beta; Unconventional protein secretion
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Funding
- Deutsche Forschungsgemeinschaft [SFB/TRR 186/A1, SFB/TRR 83/A5, Ni 423/10-1]
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Fibroblast growth factor 2 (FGF2) and interleukin 1 beta (IL-1 beta) were among the earliest examples of a subclass of proteinswith extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and Golgi-independent manner. Many years later, a number of alternative secretory pathways have been discovered, processes collectively termed unconventional protein secretion (UPS). In the course of these studies, unconventional secretion of FGF2 and IL-1 beta were found to be based upon distinct pathways, mechanisms and molecular machineries. Following a concise introduction into various pathways mediating unconventional secretion and transcellular spreading of proteins, this Cell Science at a Glance poster article aims at a focused analysis of recent key discoveries providing unprecedented detail about the molecular mechanisms and machineries driving FGF2 and IL-1 beta secretion. These findings are also highly relevant for other unconventionally secreted cargoes that, like FGF2 and IL1 beta, exert fundamental biological functions in biomedically relevant processes, such as tumor-induced angiogenesis and inflammation.
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