Journal
CRYSTAL GROWTH & DESIGN
Volume 15, Issue 12, Pages 5839-5848Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.5b01219
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Funding
- Eli Lilly, Indiana, USA
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Automated direct nucleation control (ADNC) is a focused beam reflectance measurement-based feedback control approach that is used to produce large and uniform crystals in batch cooling crystallization. In this work, this feedback control approach is modified to work for continuous cooling crystallization processes, including single-stage and multistage mixed suspension mixed product removal crystallizers. The proposed continuous ADNC approach is observed to provide quick startup, high quality control of crystal size distribution, as well as automated and effective disturbance suppression.
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