Journal
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
Volume 39, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colcom.2020.100320
Keywords
Magnetic nanoparticles; N-halamine coating; Dopamine; Mussel-inspired; Antibacterial use
Funding
- National Natural Science Foundation of China [21304044, 51663019]
- Natural Science Foundation of Inner Mongolia Autonomous Region [2015MS0520, 2019JQ03]
- State Key Laboratory of Medicinal Chemical Biology [201603006, 2018051]
- Program of Higher-Level Talents of Inner Mongolia University [30105-125136]
- State Key Laboratory of Polymer Physics and Chemistry [2018-08]
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Antibacterial N-halamine coatings are successful in avoiding and eliminating bacterial infections caused by bacterial contamination and biofilms on the surfaces. However, the N-halamine coatings remain a long-standing challenge faced by our healthcare system. Herein we reported a new mussel-inspired surface modification strategy to achieve N-halamine copolymer coatings with adhesive effects. The phenolic hydroxyl groups from Nhalamine copolymers are used for ligand exchange with oleic acid on the magnetic Fe3O4 nanoparticles for binding the N-halamine copolymer onto the surface of the nanoparticles. The as-synthesized N-halamine coatings endow the magnetic Fe3O4 nanoparticles antibacterial activity toward both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Since the super-paramagnetism of Fe3O4 in core, the N-halamine coatings are separable magnetically and remain high inactivating efficiency toward bacteria even after five cycles. We believe that, with the advantage of mussel-inspired strategy, the N-halamine coatings should have great potential for use in antibacterial and biomedical fields.
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