Journal
DIFFERENTIATION
Volume 116, Issue -, Pages 16-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2020.10.002
Keywords
CircRNAs; LncRNAs; Osteogenesis; Osteoclastogenesis; Osteoporosis
Categories
Funding
- National Natural Science Foundation of China [51935014, 81871494, 81871498, 81572577, 82072084]
- Hunan Province Natural Science Foundation of China [2019YZ3020]
- Jiangxi Provincial Natural Science Foundation of China [20192ACB20005]
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Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through a variety of pathways, and are considered as targets for the prophylaxis and treatment of osteoporosis. Based on an in-depth understanding of their roles and mechanisms in osteoporosis, we summarize the functions and molecular mechanisms of circRNAs and lncRNAs involved in the progression of osteoporosis and provide some new insights for the prognosis, diagnosis and treatment of osteoporosis.
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