Journal
JAPANESE DENTAL SCIENCE REVIEW
Volume 56, Issue 1, Pages 38-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jdsr.2019.08.001
Keywords
R2TP; PAQosome; Chaperone; HNSCC; OSCC; Cancer drugs
Categories
Funding
- JSPS KAKENHI [JP18I, 09504]
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R2TP/PAQosome (particle for arrangement of quaternary structure) is a novel multisubunit chaperone specialized in the assembly/maturation of protein complexes that are involved in essential cellular processes such as PIKKs (phosphatidylinositol 3-kinase-like kinases) signaling, snoRNP (small nucleolar ribonucleoprotein) biogenesis, and RNAP II (RNA polymerase II) complex formation. In this review article, we describe the current understanding of R2TP/PAQosome functions and characteristics as well as how the chaperone complex is involved in oncogenesis, highlighting DNA damage response, mTOR (mammalian target of rapamycin) pathway as well as snoRNP biogenesis. Also, we discuss its possible involvement in HNSCC (head and neck squamous cell carcinoma) including OSCC (oral squamous cell carcinoma). Finally, we provide an overview of current anti-cancer drug development efforts targeting R2TP/PAQosome. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.
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