Journal
CRITICAL REVIEWS IN IMMUNOLOGY
Volume 40, Issue 3, Pages 249-253Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2020034613
Keywords
immunoscope; spectratyping; T cell receptor; repertoire; antigen specificity; next-generation sequencing
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Funding
- FISM (Fondazione Italiana Sclerosi Multipla) [cod 2016/R/22]
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The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.
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