Journal
GENOMICS
Volume 112, Issue 6, Pages 4547-4551Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2020.08.007
Keywords
Single-cell RNA sequencing; Embryonic development; Cellular heterogeneity
Funding
- Science and Technology Planning Project of Guangdong Province, China [2017B020209001]
- Natural Science Foundation of Guangdong Province, China [2017A030310629]
- Guangxi Zhuang Autonomous Region Natural Science Foundation [2017gxnsfaa198185]
- Key Laboratory Construction Project Plan of Guangxi Zhuang Autonomous Region [17259-57]
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Embryonic development is a complex process that is regulated by a series of precise cellular behaviours. The limited number of cells in the early stages of embryonic development represents a challenge for studying early gene regulation and maintaining cell sternness. Single-cell sequencing is a new technology for high-throughput sequencing analysis at the single-cell level that not only reflects the heterogeneity between cells but also reveals gene expression characteristics in different cells from limited samples. Currently, the widespread application of single-cell RNA sequencing technology is gradually changing our understanding of disease pathogenesis. This article reviews the application of single-cell RNA sequencing in embryonic development in recent years and provides innovative ideas for research on embryonic development and the treatment of diseases related to embryonic development.
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