Journal
SEMINARS IN IMMUNOLOGY
Volume 49, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2020.101435
Keywords
Resident memory (T-RM); Stem cell memory (T-SCM); Effector memory (T-EM); Central memory (T-CM); Tumor immunity; Exhaustion
Categories
Funding
- American Cancer Society [CSDG18-167-01]
- Society of Surgical Oncology Clinical Investigator Award
- NIH [R01 CA225028]
- Knights of the York Cross of Honour Philanthropic Fund
- Borroughs Welcome BDLS Training Grant
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Long-lived memory CD8(+) T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8(+) T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8(+) T cell subsets together orchestrate durable immunity to cancer.
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