Journal
EMERGENT MATERIALS
Volume 3, Issue 3, Pages 407-425Publisher
SPRINGERNATURE
DOI: 10.1007/s42247-020-00109-x
Keywords
Mesoporous silica nanoparticles; Drug delivery; Endogenous and exogenous stimuli; Anticancer drug delivery; Targeting
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Funding
- Qatar University [QUHI-CAS-19/20-1]
- Qatar National Library, Doha, Qatar
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Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their cargo upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and multistage targeting, are discussed.
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