Journal
DATA IN BRIEF
Volume 33, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dib.2020.106592
Keywords
Curcuma longa; Aromatic-turmerone; Antiplasmodial activities; Plasmodium falciparum; Stage-specific inhibition
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Funding
- Malaysian Ministry of Education (MOE) [FRGS/1/2019/STG03/UKM/03/2]
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Aromatic (ar)-turmerone is one of the aromatic constituents abundant in turmeric essential oil from Curcuma longa. Ar-turmerone exhibited anti-inflammatory properties. So far, antiplasmodial data for ar-turmerone is still not reported. The data showed the in vitro antiplasmodial effect of ar-turmerone against Plasmodium falciparum 3D7 (chloroquine-sensitive) via Plasmodium lactate dehydrogenase assay (pLDH) and cytotoxic effect against Vero mammalian kidney cells using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) colourimetric assay. Selectivity indexes of ar-turmerone were calculated based on inhibition concentration at 50% of parasite growth (IC50) from MTT and pLDH assays and the effects of ar-turmerone were compared to the antimalarial reference drug chloroquine diphosphate. The inhibitory effect of ar-turmerone at the intraerythrocytic stages of plasmodial lifecycles was evaluated via a stage-dependant susceptibility test. The antiplasmodial and cytotoxic activities of ar-turmerone revealed IC50 values of 46.8 +/- 2.4 mu M and 820.4 +/- 1.5 mu M respectively. The selectivity index of ar-turmerone was 17.5. Ar-turmerone suppressed the ring-trophozoite transition stage of the intraerythrocytic life cycle of P. falciparum 3D7. (C) 2020 The Authors. Published by Elsevier Inc.
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