Journal
MATERIALS TODAY ADVANCES
Volume 8, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtadv.2020.100117
Keywords
Biomaterials; Tumor model; Cancer cells; Extracellular matrix; Tumor microenvironment
Categories
Funding
- National Institutes of Health [U01 HL143403, UL1 TR002529, R01 CA211098, R01 DK112778]
- National Science Foundation (STC-EBICS) [CBET-0939511, CBET-1932192]
- Purdue Center for Cancer Research [P30 CA023168]
- Laura Winkelman Davidson Fellowship
- Walther Embedding Program in Physical Sciences in Oncology
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Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently extended to recapitulate the in vivo tumor microenvironment, including biological, chemical, and mechanical conditions tailored for specific cancer type and its microenvironment. In spite of the recent emergence of various innovative engineered tumor models, many of these models are still early stage to be adapted for cancer research. In this article, we review the current status of biomaterials engineering for tumor models considering three main aspects-cellular engineering, matrix engineering, and engineering for microenvironmental conditions. Considering cancer-specific variability in these aspects, our discussion is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma. In addition, we further discussed the current challenges and future opportunities to create reliable and relevant tumor models. (C) 2020 The Author(s). Published by Elsevier Ltd.
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