Journal
ROMANIAN JOURNAL OF INTERNAL MEDICINE
Volume 58, Issue 4, Pages 199-208Publisher
SCIENDO
DOI: 10.2478/rjim-2020-0017
Keywords
Kaposi sarcoma-associated herpesvirus; KSHV; Kaposi sarcoma; primary effusion lymphoma; multicentric Castleman disease
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Human herpesvirus 8 (HHV8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for diagnosis and treatment. Therefore, ongoing studies are trying to answer the main issues related to the management of KSHV infection and its associated diseases. This review updates the current knowledge of the KSHV infection, discussing aspects related to epidemiology, virological features, clinical manifestations, diagnosis and treatment.
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