Journal
C-JOURNAL OF CARBON RESEARCH
Volume 6, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/c6040075
Keywords
chloroquine; square-wave voltammetry; boron-doped diamond; electroanalysis; pharmaceutics
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Funding
- CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTIFICO E TECNOLOGICO (CNPq) [303338/2019-9]
- COORDENACAO DE APERFEICOAMENTO DE PESSOAL DE NIVEL SUPERIOR (CAPES) [88887.504861/2020-00, 001]
- FUNDACAO DE AMPARO A PESQUISA DO ESTADO DO SAO PAULO (FAPESP) [2017/21097-3, 2020/01050-5]
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In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (-0.5 A cm(-2) by 180 s, generating a predominantly hydrogen-terminated surface) and anodic (+0.5 A cm(-2) by 30 s, oxygen-terminated surface) pretreatments. The cathodically pretreated BDD electrode ensured a better-defined anodic peak and higher current intensity. Thus, by applying the cathodically pretreated BDD electrode and square-wave voltammetry (SWV), the analytical curve was linear from 0.01 to 0.25 mu mol L-1 (correlation coefficient of 0.994), with sensitivity and limit of detection of 12.2 mu A L mu mol(-1) and 2.0 nmol(-1), respectively. This nanomolar limit of detection is the lowest recorded so far with modified and unmodified electrodes.
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