Journal
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
Volume 13, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1178646920972657
Keywords
Tryptophan; Kynurenine; Alzheimer; APP23; tryptophan 2; 3-dioxygenase; TDO; aging
Categories
Funding
- Research Foundation-Flanders (FWO)
- Special Research Fund UAntwerpen (Bijzonder Onderzoeksfonds, BOF) [34423]
- Institute Born-Bunge
- University of Antwerp
- Alzheimer Research Center Groningen (UMCG, The Netherlands)
- Medical Research Foundation Antwerp
- Thomas Riellaerts research fund
- Neurosearch Antwerp
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Alzheimer's disease (AD) is associated with progressive endogenous neurotoxicity and hampered inflammatory regulation. The kynurenine (Kyn) pathway, which is controlled by tryptophan 2,3-dioxygenase (TDO), produces neuroactive and anti-inflammatory metabolites. Age-related Kyn pathway activation might contribute to AD pathology in humans, and inhibition of TDO was found to reduce AD-related cellular toxicity and behavioral deficits in animal models. To further explore the effect of aging on the Kyn pathway in the context of AD, we analyzed Kyn metabolite profiles in serum and brain tissue of the APP23 amyloidosis mouse model. We found that aging had genotype-independent effects on Kyn metabolite profiles in serum, cortex, hippocampus and cerebellum, whereas serum concentrations of many Kyn metabolites were reduced in APP23 mice. Next, to further establish the role of TDO in AD-related behavioral deficits, we investigated the effect of long-term pharmacological TDO inhibition on cognitive performance in APP23 mice. Our results indicated that TDO inhibition reversed recognition memory deficits without producing measurable changes in cerebral Kyn metabolites. TDO inhibition did not affect spatial learning and memory or anxiety-related behavior. These data indicate that age-related Kyn pathway activation is not specific for humans and could represent a cross-species phenotype of aging. These data warrant further investigation on the role of peripheral Kyn pathway disturbances and cerebral TDO activity in AD pathophysiology.
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