Journal
IEEE SENSORS JOURNAL
Volume 17, Issue 18, Pages 5915-5919Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2017.2734885
Keywords
Photonic crystals; silicon photonics; optical biosensors; microcavities; antibiotics
Funding
- Army (USAMRAA) [W81XWH-14-C-0029]
- AFOSR MURI [FA9550-08-1-0394]
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Photonic crystal (PC) microcavities formed by 2-D air holes on silicon-on-insulator substrates were utilized as biosensors to detect antibiotics with high specificity. The antibiotic, gentamicin, with molecular weight of only 478 g/mol, was successfully detected via its binding to corresponding antibody pre-immobilized on the sensor surface. Detection range (in concentration) was extended by combining different types of PC biosensors on a single silicon chip, covering from 0.1 nM to 1 mu M. Specificity of detection was also verified on the studied antibiotic.
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