Journal
FITOTERAPIA
Volume 147, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104761
Keywords
Polyketide biosynthesis; Cytochrome P450; Transcriptome analysis; Metabolomics; Plumbagin; Polyketide cyclase; Aldo-keto reductases
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Funding
- Special Assistance Programme (SAP) DSA-I, UGC, New Delhi, India [UGC-284]
- Department Research and Development Grant (DRDP) from Savitribai Phule Pune University, Pune
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Plumbagin is a pharmacologically active naphthoquinone present in the Plumbago zeylanica L. having important medicinal properties. The root of P. zeylanica is rich and primary tissue of the plumbagin biosynthesis and accumulation. The complete biosynthetic pathway of plumbagin in plant is still obscure. The present study attempts to understand the plumbagin biosynthetic pathway with the help of differential transcriptome and metabolome analysis of P. zeylanica leaf and root. The transcriptome data showed co-expression of Aldo-keto reductase (PzAKR), Polyketide cyclase (Pzcyclase) and Cytochrome P450 (PzCYPs) transcripts along with the Polyketide synthase (PzPKS) transcripts. Their higher expression in root as compared to leaf supports their possible involvement in plumbagin biosynthesis. The metabolome data of leaf and root revealed naphthalene derivative isoshinanolone that could be potential precursor of plumbagin. Pathway elucidation and transcriptome data of P. zeylanica, will enable and accelerate research on naphthoquinone biosynthesis in plants.
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