Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 5, Issue 11, Pages 1149-1162Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.07.008
Keywords
animal model; microarray; micro-RNA; pulmonary arterial hypertension
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Funding
- Fundacao para Ciencia e Tecnologia [POCI-01-0145-FEDER-032414]
- European Regional Development Fund through the Operational Program for Competitiveness Factors [POCI-01-0145-FEDER-016385, CENTRO-01-0145-FEDER-000012-N2323, POCI-01-0145-FEDER-007440, CENTRO-01-0145-FEDER-032179, POCI-01-0145-FEDER-022122, UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020]
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Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the rote of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204). (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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