Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 233, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2020.104985
Keywords
Lipid membranes; Phase separation; Membrane proteins; Membrane curvature; Supported lipid bilayer; Cytoskeleton
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Biological membranes are fluid, dynamic and heterogeneous, with the dual tasks of defining cell compartments and facilitating communication between them. Within membranes, lipid phase separation can alter local composition, dynamics, and allosteric regulation of membrane proteins. The interplay between lipid-lipid, lipid-protein and protein-protein interactions gives flexibility to membrane lateral organization. In this review we examine how lipid phase separation impacts lateral transport of lipids and proteins within membranes. First, we discuss the role of liquid-liquid coexistence in the organization of model biomembranes, and how such demixing can redistribute lipids and proteins into different regions. Next, the role of curvature in membrane patterning via its influence on lipid composition and protein spatial distribution in both model and biological systems is examined. Then, we discuss how critical fluctuations can organize membrane proteins. Finally, we review how external forces can be used to control the organization of lipids and proteins within biomembranes; with examples covering how ATP driven protein adsorption, electrophoresis, and hydrodynamic flow can transport and redistribute lipids and proteins laterally within membranes.
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