Journal
TOXICOLOGY REPORTS
Volume 7, Issue -, Pages 583-595Publisher
ELSEVIER
DOI: 10.1016/j.toxrep.2020.04.010
Keywords
Biomarkers; Epigenetics; Environment; Gene regulation; Non-coding RNAs; Toxicity
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Funding
- Science and Engineering Research Board Empowerment and Equity Opportunities for Excellence in Science [EEQ/2018/000633]
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The advent of new technologies has paved the rise of various chemicals that are being employed in industrial as well as consumer products. This leads to the accumulation of these xenobiotic compounds in the environment where they pose a serious threat to both target and non-target species. miRNAs are one of the key epigenetic mechanisms that have been associated with toxicity by modulating the gene expression post-transcriptionally. Here, we provide a comprehensive view on miRNA biogenesis, their mechanism of action and, their possible role in xenobiotic toxicity. Further, we review the recent in vitro and in vivo studies involved in xenobiotic exposure induced miRNA alterations and the mRNA-miRNA interactions. Finally, we address the challenges associated with the miRNAs in toxicological studies.
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