4.7 Article

A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 93, Pages 14613-14616

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06582j

Keywords

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Funding

  1. National Natural Science Foundation of China [81472401, 81772708]
  2. Research Grants Council of Hong Kong [C6009-17G]
  3. Innovation and Technology Commission [ITC-CNERC14SC01]
  4. Natural Science Foundation of Jiangsu Province [BK20190175]
  5. Science and Technology Project for the Youth of Suzhou [KJXW2018006]

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A new ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting intracellular HClO/ClO- in living cells and discriminating cancer cells from normal cells. Based on the ratiometric fluorescence properties conferred by the AIE and DTBET effects, this probe has excellent sensitivity and specificity for the HCIO response.

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