Involvement of single nucleotide polymorphisms in acute lymphoblastic leukemia susceptibility

Acute lymphoblastic leukemia (ALL) is an overgrowth of lymphoid progenitor cells and accounts for the highest common type of childhood cancer. Early detection of ALL could significantly improve the treatment and thereby survival of the patients. Single Nucleotide Polymorphisms (SNPs) have been emerging as effective diagnostic biomarkers in cancer. However, little is known about the association between the SNPs and the risk of ALL. In this study, we genotyped ALL patients and controls for eight SNPs, using the Tetra-primer ARMS PCR method. The results showed there were significant associations between the rs1333048, rs2070672, rs2279744, rs3733890, rs11549465 and the risk of ALL cancer. The findings may have diagnostic implications for early detection of ALL.