Journal
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
Volume 3, Issue 6, Pages 1361-1370Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsptsci.0c00163
Keywords
SARS-CoV-2; virtual screening; ACE2; romidepsin; molecular dynamics; HDAC inhibitors
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Funding
- Chinese Academy of Sciences
- Shenzhen Institutes of Advanced Technology, CAS, Shenzhen government
- Guangdong province [2019QN01Y306]
- National Natural Science Foundation of China [31671397]
- Shenzhen Science and Technology Program [JCYJ20170818153538196]
- COVID-19 emergency tackling research project of Shandong University [2020XGB03]
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The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
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