Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 46, Issue 6, Pages 972-988Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162020060151
Keywords
type 2 diabetes mellitus; GPR40; FFA1; phenylpropanoic acid; hypoglycemic activity; FFA1 receptor agonists
Funding
- Russian Science Foundation [20-13-00029]
- Russian Science Foundation [20-13-00029] Funding Source: Russian Science Foundation
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Free fatty acid receptor-1 (FFA1) agonists have been considered for a long time as a potentially new class for the treatment of type 2 diabetes mellitus. Phenylpropanoic acid is the preferred scaffold in the development of FFA1 receptor agonists. This review analyzes the effect of structural fragments of phenylpropanoic acid-based agonists on receptor affinity, selectivity, biocompatibility, and metabolic stability. Current trends in the design of FFA1 receptor agonists are discussed.
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