Journal
IEEE JOURNAL OF SOLID-STATE CIRCUITS
Volume 52, Issue 2, Pages 543-555Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2016.2621036
Keywords
Biosensor; CMOS; flow cytometer; magnetic; microfluidics; miniature
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A flow cytometer chip fabricated in 65-nm standard CMOS technology embedded into a microfluidic channel is presented. The chip detects cells specifically tagged with magnetic labels by demodulating the change in coupling between an excitation coil and a pickup coil of a differential spiral transformer. Operation of the flow cytometer cartridge is verified for the detection of SKBR-3 breast cancer cells tagged with manganese ferrite magnetic labels using EpCAM-biotin-streptavidin chemistry. Magnetic labels of different materials are classified by the difference in the phase of their complex susceptibility.
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