Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 12, Pages 8603-8610Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00990
Keywords
spherical nucleic acid; scar; nanomedicine; topical; gene regulation; TGF-beta
Funding
- NTU-NU Institute for NanoMedicine located at the International Institute for Nanotechnology, Northwestern University, U.S.A.
- Nanyang Technological University, Singapore
- National Cancer Institute of the National Institutes of Health [U54CA199091]
- Air Force Research Laboratory [FA8650-15-2-5518]
- National Science Foundation East Asia and Pacific Summer Institutes for U.S. Graduate Students (EAPSI) program
- National Science Foundation Graduate Research Fellowship Program
- Eden and Steven Romick Post-Doctoral Fellowship through the American Committee for the Weizmann Institute of Science
- City University of Hong Kong [9610472]
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF) [ECCS1542205]
- MRSEC program (NSF) at the Materials Research Center [DMR-1720139]
- International Institute for Nanotechnology (IIN)
- State of Illinois, through the IIN
- MRI program [NSF DMR1229693]
- National Institutes of Health [NIAMS P30 AR057216]
- Robert H. Lurie Comprehensive Cancer Center [NCI P30-CA060553]
- Chemistry for Life Processes Institute
- NU Office for Research
- Rice Foundation
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Abnormal scarring is a consequence of dysregulation in the wound healing process, with limited options for effective and noninvasive therapies. Given the ability of spherical nucleic acids (SNAs) to penetrate skin and regulate gene expression within, we investigated whether gold-core SNAs (AuSNAs) and liposome-core SNAs (LSNAs) bearing antisense oligonucleotides targeting transforming growth factor beta 1 (TGF-beta 1) can function as a topical therapy for scarring. Importantly, both SNA constructs appreciably downregulated TGF-beta 1 protein expression in primary hypertrophic and keloid scar fibroblasts in vitro. In vivo, topically applied AuSNAs and LSNAs downregulated TGF-beta 1 protein expression levels and improved scar histology as determined by the scar elevation index. These data underscore the potential of SNAs as a localized, self-manageable treatment for skin-related diseases and disorders that are driven by increased gene expression.
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