Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 12, Pages 8338-8343Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00554
Keywords
polysaccharide; ultrafast degradation; tough hydrogel; biocompatibility; wound repair
Funding
- National Natural Science Foundation of China [51903209]
- Natural Science Foundation of Shaanxi Province [2018JM4043]
- Natural Science Basic Research Project of Shaanxi Province [2018JQ3071]
- National Innovation and Entrepreneurship Training Program for College Students [S202010699021X]
- Analysis and Testing Center of the School of Life Sciences in Northwestern Polytechnical University
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Repeatedly changing dressings during wound healing can cause unbearable physical pain for patients with chronic skin injury. In this study, we designed a tough hydrogel-based dressing that can be degraded in an on-demand fashion for advanced chronic wound care. The resultant hydrogel dressing could be rapidly dissolved within 100 s after wetting with lithium phenyl(2,4,6-trimethylbenzonyl)phosphinate solution under low-power (1 W) ultraviolet (UV) irradiation (365 nm) owing to the breakage of disulfide bonds. This UV-triggered on-demand dissolution of tough hydrogels allows for a facile dressing replacement without causing tissue damage or pain, which is of great potential for clinical utilization.
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