Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 7, Pages 3928-3934Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00149
Keywords
artificial cells; DNA nanotechnology; DNA nanostructures; bionic elements; cellular microenvironment
Funding
- National Natural Science Foundation of China [31671003, 21874092]
- Innovative research team of high-level local universities in Shanghai
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Artificial cells have led to many potential applications in synthetic biology and served as useful platforms to study biological phenomena. With increasing development of DNA nanotechnology, DNA-based nanostructures with various morphologies have been constructed for protein mimicking. These biomimicking elements can be assembled on cell membrane involved in various cellular activities, as well as be constructed as signaling networks inside cells. DNA nanotechnology provides an efficient approach to accomplish multiple functions, including signal recognition, transduction, and output. Here, we review a myriad of predominant studies on the construction of artificial cells based on DNA nanotechnology, including the morphological and functional mimic of membrane proteins, biosensors for monitoring the cellular microenvironment, and construction of DNA-based signal feedback networks. We also provide a comprehensive insight into DNA-based artificial cells, on the basis of current challenges and scientific requirements, which will prompt their reasonable designs in the future.
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