Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 7, Pages 4590-4599Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00499
Keywords
aptamers; gold nanostars; on-demand drug release; targeting delivery; photothermal effect
Funding
- Guangdong Basic and Applied Basic Research Foundation [2019A1515010696]
- Fundamental Research Funds for the Central Universities [19lgpy121]
- Shenzhen Municipal Science, Technology and Innovation Commission [JCYJ20190807163003704]
- 100 Talents Program of the start-up foundation from Sun Yat-sen University
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Gold nanostars (AuNS) are promising carriers for targeted delivery of therapeutic oligonucleotides, but their potential in fabricating an on-demand drug release system in a facile and robust way remains to be explored. In this paper, we used a model aptamer (HApt), acting not only as a target ligand but also as a natural thermal-responsive material, to decorate AuNS. The prepared gold nanoconstruct, HApt@AuNS, displayed stoichiometric loading capacity of the anthracycline drug doxorubicin (Dox). The ondemand drug release was realized by illuminating nanoconstructs with near-infrared (NIR) light. Furthermore, a higher degree of Dox release from the nanoconstructs was achieved in an acidic environment, compared to neutral conditions. The in vitro experiments showed that Dox-intercalation did not affect the cell uptake efficiency of HApt@AuNS, which could enter cells through clathrin-mediated endocytosis and microtubule-dependent active transport to lysosomes. Dox-loaded HApt@AuNS exhibited intracellular on-demand drug release and enhanced toxicity against cancer cells by NIR-irradiation.
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