Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 11, Pages 7265-7277Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00916
Keywords
structural DNA nanotechnology; 3D cages; bioimaging; targeted delivery; biomedical applications
Funding
- IITGN-MHRD, GoI
- SERB, GoI
- BRNS-BARC GoI
- IITGN
- SERB
- MHRD
- DST-SERB
- GSBTM, GoI
Ask authors/readers for more resources
DNA nanotechnology is a unique field that provides simple yet robust design techniques for self-assembling nanoarchitectures with extremely high potential for biomedical applications. Though the field began to exploit DNA to build various nanoscale structures, it has now taken a different path, diverging from the creation of complex structures to functional DNA nanodevices that explore various biological systems and mechanisms. Here, we present a brief overview of DNA nanotechnology, summarizing the key strategies for construction of various DNA nanodevices, with special focus on three-dimensional (3D) nanocages or polyhedras. We then discuss biological applications of 3D DNA nanocages, particularly tetrahedral DNA cages, in their ability to program and modulate cellular systems, in biosensing, and as tools for targeted therapeutics. We conclude with a final discussion on challenges and perspectives of 3D DNA nanodevices in biomedical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available